|
KMID : 0882420130850030229
|
|
Korean Journal of Medicine
2013 Volume.85 No. 3 p.229 ~ p.239
|
|
|
The Concept and Overview of Spondyloarthritis
|
|
Seo Mi-Ryoung
Baek Han-Joo
|
|
|
Abstract
|
|
|
|
The spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases in association with HLA-B27. They share the clinical features including sacroiliitis, spondylitis, oligoarthritis, enthesitis and extra-articular involvement. Recently ASAS proposed new classification criteria sets of axial and peripheral SpA. They were designed to include non-radiographic SpA, thus can guide the early diagnosis of disease before the structural damage occurs. SpA has a strong genetic predisposition. Non-MHC genes, such as IL23R and ERAP1, as well as HLA-B27 were confirmed as susceptibility genes through several GWAS. Major pathology in SpA is entheseal inflammation and new bone formation. Intrinsic ability of HLA-B27 to trigger innate immune response and several proinflammtory cytokines may contribute to the inflammation in SpA. New bone formation could be explained by a mechanism, partly or completely independent of the inflammatory process.
|
|
|
KEYWORD
|
|
|
Spondyloarthritis, Ankylosing spondylitis, Inflammatory back pain, HLA-B27
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|